In this educational session, there will be a discussion about our current understanding of the genomic landscape of breast cancer. This will include what a genomic alteration or aberration is, what different types of genomic alterations exist, what tests can be used to identify them, and what findings we might expect in breast cancer. Finally, there will be a commentary on the clinical relevance of genomic alterations in breast cancer, and whether this type of testing should be considered as part of routine care now and in the future.