The Access to Oncology Medicines Coalition (ATOM Coalition), led by the Union for International Cancer Control (UICC), is a ground-breaking initiative in collaboration with over 40 global organisations across the public, private and civil society sectors. It aims to reduce cancer-related suffering and deaths by addressing the barriers to availability, affordability, and appropriate use of oncology medicines in low- and lower-middle income countries (LLMICs). Building on UICC’s long-standing advocacy for the global availability of cancer medicines, the ATOM Coalition was created under UICC’s leadership in 2022 to further drive collective, coordinated action across the public, private and civil society sectors at the global and country level. The presentation will provide an overview of the current challenges to access to oncology medicines in LLMICs, the ATOM Coalition operating model and how it intends to address key barriers to access.